Bioenergetic dysfunctions, mitochondrial NAD+NADH [ H+] pool and tumour microenvironment FAD & FMN Mitochondrial Metabolism + TRANSPORT; ADENYLATE CHARGE in DIFFERENT PHYSIOLOGICAL & PATHOLOGICAL CONDITIONS ( i.e. STRESSFUL & Extremely Adverse Environmental + Appropriate Immunometabolites as an Indicator of Resilience) Project: Innovative markers in disease prevention (i.e. COVID-19 pandemic) and personalized medicine (4P) More that meets the eye