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Curriculum - Prof.ssa Maria Luigia PALLOTTA

Curriculum

  • Maria Lui Maria Luigia Pallotta, Bio[chemist/physicist] ATTENTION FAKE SCIENTIST & FALSIFICATORS QI <<150 STAY  TUNED!!! CAGE

    THINKER & SCHOOLAR

    Royal Society Medicine FELLOW from 2021

    American Association for Advancement of the Sciences (AAAS) MEMBERSHIP 2019

    BENTHAM SCIENCE AMBASSADOR from 2019


    Maria Luigia  Pallotta,  Biochemist/Biophysicist

    Maria L R ROYAL SOCIETY OF MEDICINE Fellow, AAAS membership

    Bentham  Bentham SCIENCE AMBASSADOR mail maria.pallotta@gov.

     

     

     

     

     

    500500women scientists - Pis    Pod Cb(MOLISE)MLP

    @500w Organizzazione no-profit
    A grassroots movement started by a group of women scientists in the US, with the aim to make science open, inclusive and accessible.
    Why do we need a 500womenscientists movement in Italy?
    Because across the globe, women in science face discrimination, harassment, unequal pay, and reduced opportunities. Instead of fighting alone against patriarchy, racism and oppressive societal norms, let’s take action and transform society together.
    Let’s
    - create a support network for women scientists here in Pisa where we can share personal and professional experiences
    - reach out to the local community, especially girls and members of minority groups, to encourage scientific interest and discourse,
    - confront sexual discrimination and harassment and any other forms of injustice and inequality in science
    - build a fair and inclusive scientific community dedicated to training a more diverse and thoughtful group of researchers
    - connect with other European pods to strengthen interactions between women scientists across Europe
    - have fun together in and outside science

    Full  Time Permanent Researcher  (SSDBIO/10)/Aggregate Professor,

    Department of Medicine and Health Sciences, "V. Tiberio"-

    University of Molise- Via deSanctis-86100 Campobasso (ITALY).

    Office Tel:

    Mobile phone +39. 392. 1528730 -

    E-mail: p      pallottamarialuigia@gmail.com / pallotta@unimol.it

     

    -http://do        maria.pallotta@gov. docenti.unimol.it/index.php?u=pallotta

    • She received her STA Master Degree from University of Bari-Italy  score 110/110, with dissertation on Food Chemistry- experimental thesis  -more 2 years at  lab of prof Pallavicini, Head of Dept Prof Catalano "Preparazione ed analisi di coprecipitati ottenuti da miscele di proteine di soia e siero di latte trattate con proteasi "-.
    • (i.e. Protein Isolation from food matrix,  protein assay, N determination in micro-Kjeldahl digests,  Protein purification,  Enzymatic Assay, Kinetics, Inhibition, SDS -PAGE, Disc.Electrophoresis, Isoelectrofocusing, HPLC, et al.)  
    •  
       She taught some years Chemistry, Biology and Astronomical Geography at high school, (i.e. Classical Liceo in Ostuni and Fasano, Brindisi, Italy) and,
    • concurrently, she attended Pallavicini ‘s lab, at University of Bari & improved her knoweledge on  Food Chemistry & Technology.
    • Moreover she worked, for free,  like pubblicist & designer together her husband TI -Urban Planner & Landscape Architect +SpatialAnalyst GIS -GIS Web-
    • & for organizing charity events with her friends (on 7 March, 1991 arrived to Brindisi 25000 people from Albania, it was a major  emergency)
    •  
    • After winning a public competition, she joined at University of Molise, October 1991
    • Dipartimento Agricoltura, Ambiente e Alimenti from 1991- to 1993
    • Dipartimento  Scienze Animali, Vegetali, Ambientali, from 1994-to 2001
    • Centro Ricerca e Servizio di Ateneo per la Formazione “G.A. Colozza”  from 2002- to 20005
    • Dipartimento di Medicina e di Scienze della Salute from 2005 to 2021
    •  
    • National scientific eligibility  as -Full-time position- as Permanent Researcher (Settore Concorsuale G05, Microbiology,Technology & Agricultural Chemistry, bando PDN 205, del 29/10/1993 GUN 98 bis del 10/12/93) University of Udine,  oral score 10/10

    • Permanent Researcher (Settore Concorsuale BIO/10 Biochemistry) 2002

    •  

    • Training

    • Proteins Separation– Institute of Neurobiology,  National Research Council (CNR)–Rome 1993 

    • Capillary Electrophoresis –Institute of Neurobiology National Research Council (CNR)–Rome 1993 

    • Molecular Biology in diagnostic - BioResearch Center -Milan 1993

    • The Digoxigenin System for the Labeling and Detection of Nucleic Acids, National Research Council (CNR)  Bari 1994

    • Molecular Biology–Advanced course, Biomedical International Science Park  San Raffaele Milan, 1995 

    • LC/MS advanced techniques in HPLC Perkin Elmer, Rome 1996 

    • 7th European PCR Seminar Tour, Università Cattolica Sacro Cuore, Faculty of Medicine, Rome 1996 

    • HLA typing by sequencing: comparing experiences, Center of Advanced Biotechnology, San Martino’s   Hospital, Genoa 1997  

    • Bio-technology applied to molecular diagnostic Center of studies on Mitochondria and Energetic Metabolism  - SIBIOC Trani (Bari) 1997

    • Quantitative PCR- State of Art and new technology-Group of Clinical Biochemistry, University of Florence, 1998

    • Progetto Proteoma -Techniche integrate per lo studio di proteine, Perkin Elmer, Roma 1998

    • Italian–Japanese Bilateral Meeting on Bioenergetics, University of Bari, 1998. 

    • Shaping the future: the impact of structural biology- M. Brunori (La Sapienza), R. Huber (Nobel Laureate), J. Walker (Nobel Laureate), D. Wiley (Harvard University), K.Holmes (Max Planck Institut fur Medizinische Forschung), S. Harrison. Rome 1999 

    • Genes and Responsibility ‘s civil Scientist - G. Martini,G. Corbellini, E. Boncinelli, J. Beckwith, U. di Porzio. Italian Institute for Philosophical Studies, Naple, 2000

    • The next revolution: bio e biotec- J. Meldolesi, B. Sitia, F. Terragni, House of Culture, Milan 2000.

    • Structure and dynamics of RNA and DNA viruses –J.Johnson, the SCRIPP Research Institute La Jolla, L Gehrke Harvard Medical School,  Boston December 2000.

    • MFCS/win Basic operator training- Braun Biotech International Biostat B Bioreactor System that covers a wide range of applications, extending from use as a flexible basic unit for preclinical research to a fully qualified system that complies with the requirements of a validated GMP environment.  Campobasso, 2001

    • Microarray User’s Meeting-Istituto Nazionale Malattie infettive “L. Spallanzani”, Roma, 2001.

    • 1st International Meeting on Yeast Apoptosis, University of Minho, Braga, Portugal  2002. 

    • Yeast as a test tube for pharmacological drugs screening University of Washington, Seattle, WA. July- August, 2004

    • Mobility: a space for the exploitation of research. Rome, National Research Council (CNR), 2005 

    • World Day of Intellectual Property, Ministry of Economic Development, 2005, Rome.

    • Microfluids: lab-on-a-chip technology for protein and nucleic acid assays  “ Experion System” – Campobasso, 2006 

    • Nuove tecnologie e Sviluppi nell’analisi del Proteoma, Medical School,Università degli Studi di Roma "Tor Vergata"2006 

    •  Database searching-Basic Rules & Tools-FEBS working group on Teaching Biochemistry in Europe, Istanbul 2006
    • 3rd International Conference on Functional Genomics of Aging, ISMETT Palerm 2007 (only listener)
    • 3rd Cell Stress Society International Congress on Stress responses in Biology and Medicine and 2nd Word Conference of Stress Budapest 2007 
    • Use of ultra-performance liquid chromatography (UPLC) for making real-time pooling decisions for process chromatography-Waters, CB 2008
    • EndNote and EndNote Web, Scientific Library, National Cancer Institute,  Frederick, Maryland, US, April 2014  
    • Research Integrity Accademia Nazionale dei Lincei Rome, March 2015
    • Transdisciplinary Research in Energetics and Cancer (TREC) Workshop, ISBNPA Cancer Prevention & Management SIG, Edinburgh June 2015
    • Strategie di utilizzo e le novità della piattaforma bibliografico/citazionale per la Ricerca 'Web of Science' + InCites Benchmarking & Analytics, 2019, Biblioteca di Ateneo, Campobasso
    • 23rd Bologna Winter School "Structural Bioinformatics in the era of AlphaFold2". Feb 2022
    • A   AAAS Annual Meeting February 17-20, 2022 Held Virtually
    • WEBINAR 2020
    • Immunometabolic Analysis of Pseudomonas aeruginosa Pulmonary Infection
    • Sebastián A Riquelme, PhD
      Columbia University Medical Center
    • Mitochondrial Function using MitoPlates™ Brendan Lewis
      Specialist Biolog, Inc.
    • Analysis of Microbial Genomic and Phenotypic Data using DuctApe Software
    • Marco Galardini, Ph.D. Biolog
    • Assessing Functional Traits of Microbial Communities using EcoPlates™".
    • Understanding Antibiotic Mechanism of Action with Phenotype Microarrays™ and Machine Learning, JasonH.Yang,Ph.D.
      The Use of Biolog GEN III MicroPlates™ in the Undergraduate Unknown Microbe Identification Project, Jeffrey Newman, PhD Biology Professor Lycoming College

    •  
    •  
    • English language courses
    • English language course- during all primary schooling , with Profssa Savastano, Bojano CB
    • English language course-London July-August 1978
    •  
    • English language course-Centre of English Studies- July-August 1995 Dublin Ireland English language course for Intermediate learners”
    • Operational Program 1994/99”Research, Technological development and Advanced Training”  From May To October 2001, Campobasso  Ital    100/100 score ultimate test
    • English language course for High Intermediate learners, Malta January 2002 
    • En   Advanced course- English Language Center-Boston Massachusetts May-June 2005. 
    •  
    • Research topics:
    • Bioenergetics, metabolism and transport of metabolic biomolecules, nucleotides, cofactors and coenzymes by isolated and bioenergically active  mitochondria under physiological and stressful conditions;
    • Innovative  biomarkers for improving  diagnostics in 4Pmedicine 
    • Microbiota & nutaceuticals
    •  
    • Realization and organization of the following symposium: 
    • Meeting with joined sessions GIBB (Italian Group of Bioenergetics and Biomembranes)-Membrane and Bioenergetic Group of SIB (Italian Sociaty of Biochemistry), Prof Passarella/group team, Italy, June 1997.
    • From research to calendar Multiple Sclerosis  Supervisor Prof Pallotta 2015-2020 May 2015 Campobasso

    • Convegno Novembre 2019  Titolo: Ambiente e clima. Il presente per il futuro Luogo: Lecce - Comitato scientifico Cristina Mangia ( DS, CNR- Lecce), Patrizia Colella (DS- dirigente scolastica- Lecce), Giuliana Rubbia (DS- INGV Roma), Mariangela Ravaioli (DS- CNR Bologna) Antonella Cecchettini ( DSUni PI- CNR IFC) , Elvira Tarsitano (DS-UNIBA), Francesca Caloni (DS-UNIMI), Elena Gagliasso (DS- UNIROMA), Maria Luigia Pallotta ( DS UNIMOL), Sveva Avveduto (DS-CNR, Roma)

      2. International Pediatric Medicine Conference – Montreal, Canada

      the Organizing CommitteeRobert Weinberg, Massachusetts Institute of Technology (MIT) Na Yang, Lanzhou University School of Public Health Hugues Scharbach, Societe Medico-Psychologique Maria Luigia Pallotta, University of Molise J. Pack, M.D., Conference Chair  May  2021 Conference begins

      ESMED european Society of Medicine

       

    •  
    • Membership in scientific societies:
    • SIB (Italian Sociaty of Biochemistry)and Italian Group of Bioenergetics and Biomembranes (since 1999); Women in Science,
    • EUSTIM (European Society for Translational Medicine)2016,
    • ISM (International Society of Microbiota)  2016
    • ISHS 2019 (International Society Horticultural Sciences)
    • ESCI 2019 (European Society of Clinical Investigation) 
    • American Association for Avancement of the Sciences Membership from 2020/2022
    • Royal Society of Medicine September 2020 FELLOW 2021
    •  
    • SiBioc 2019Società Italiana di Biochimica Clinica & Biologia Molecolare Clinuca
    • Member of the council of PhD in Applied Biochemistry and Chemistry, University of Molise (from 2003 to 2005);
    • Member of the council of PhD in Health Science, University of Molise (from 2005 to 2014)
    • co-mentoring  thesis PhD abroad
    • Teaching activity   from 2002   to 2021
    • Fundamental of Instrumental Biochemistry (from 2002 to 2003)
    • Propedeutics biochemistry (from 2002 to 2014) (SMS)
    • Biochemistry, (untill now) (SMS)
    • Bioinformatics, (STA)
    • Amino Acid metabolism, (STA)
    • Nucleotide metabolism, (STA)
    • Applied Biochemistry (corso di laurea specialistica in Biotecnologie, interfacoltà Scienze Tecnologie Alimentari-STA  & Scienze Biologiche) 
    • Biochemistry (STA)
    • +4340 Student from  AA 2002/2021 + other academic experiences from 1991to 2002 Students???
    • Nutritional Biochemistry  (AA 2020/2021, AA2021/2022 corso di laurea in Scienze e cultura del Cibo
    • Academic appointments
    • She was Member of Senate (INTEGRATED) of University of Molise
    • ( From DECEMBER 1999  to January 2003)
    •  
    • She was Member of Senate of University of Molise 2003-2006, Area Activities A
    • Member of Committee for recognition credit transfer at the Faculty of Health Sciences, University of Molise, from 2003  to 2010
    • Member of Committee for the evaluation foreign students  at the Faculty of Health Sciences, University of Molise, from 2004 to 2009.
    • She was invited academic guest at Metabolism and Cancer susceptibility, Center for Cancer Research, NIH, Frederick, Washington MD United States from April to May 2014 (Research: NAD(P)+/NAD(P)H pool studies by means of Fluorescence-Based Techniques in cancer cells).
    • E’ stata componente della commissione giudicatrice per il conferimento di N.1 assegno di ricerca in Biochimica Progetto TIORCAS (Trasferimento Innovazione ed Organizzazione nella Ricerca, nella Cultura, nell’Ambiente e nella Sanità), concepito nell’ambito della iniziativa comunitaria INTERREG III/A Transfrontaliero Adriatico (Università degli Studi del Molise)with Prof SP, prof GS and myself;  the winner was Profssa NG against my judgement CB,2005 
    • E’ stata componente della commissione giudicatrice per il conferimento di N.1 Ricercatore a tempo determinato per il s.s.d. M-EDF/01 “Metodi e didattiche delle attività motorie” presso la Facoltà di Scienze del Benessere dell’Università degli Studi del Molise, with Prof Ferrara (Medicina Interna) &  Prof Daniele (Biochimica) , 2005 
    •  
    • E’ stata componente della commissione giudicatrice per il conferimento di N.1 assegno di ricerca in Biochimica “ Il canale mitocondriale del potassio in specie vegetali: effetti sulla sintesi di ATP e ruolo dei meccanismi di difesa dagli stress biotici”, Università degli Studi di Foggia, 13.04.2006.
    • E’ stata componente della commissione preposta alla valutazione delle offerte pervenute di cui all’oggetto: trattativa privata per fornitura, consegna e personalizzazione di materiale sportivo per il corso di Laurea in Scienze Motorie -with Prof Ferrara &  dottssa Cacchione-; Università degli Studi del Molise (Giugno 2004). 
    • E’ stata nominata componente delle commissioni per il conferimento dei titoli di dottore di ricerca in Biochimica e Biologia molecolare (XVI° ciclo) e Tecnologie cellulari e Molecolari in Fisiologia (XVI° ciclo), Università degli Studi di Bari (aa 2003-04);
    • E’ stata nominata componente delle commissioni per il conferimento dei titoli di dottore di ricerca in Tecnologie cellulari e Molecolari in Fisiologia (XVIII° ciclo), Università degli Studi di Bari (aa 2005-06).
    • E’ stata proponente di un progetto di didattica integrativo dal titolo”Attività integrativa, propedeutica e di recupero volta a migliorare qualitativamente l’offerta didattica e finalizzata ad assicurare ad un maggior numero di studenti la rapida progressione nelle attività curriculari previste nel corso di laurea frequentato e ridurre abbandoni e ritardi”, per
      un numero di ore pari a 44 presso il Centro Ricerca e Servizi di Ateneo per la Formazione G.A. Colozza, approvato dal Senato Accademico dell’Università degli Studi del Molise e realizzato nell’anno accademico 2002/2003.
    • E’ stata nominata Presidente della Commissione preposta alla preparazione del test“Selezione per l’accesso al primo anno del Corso di Laurea in Scienze Motorie e Sportive- per l’anno accademico 2010/2011
    • e componente in tutti gli anni accademici successivi incluso AA 2018/2019
    •  
    •  
    • Research Funding
    • COST Action CA15203  EGnaiger MitoEAGLEEvolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mappingPallotta ML MitoPedia topics: EAGLE COST: Member COST WG1: WG12018/19
    • Unimol, Dept Medicine  2016 Candidate probiotic strains, with health-improving properties, isolated from traditional Italian dairy products PIMLPallotta, with Prof Colavita & prof Gaspari
    • PRIN 2006 Genomic and proteomic approach to investigate lateral root formation in woody plant under environmental stress-component Unity of Molise University 
    • INTERREG programma TIORCAS – “Trasferimento Innovazione ed Organizzazione nella Ricerca, nella Cultura, nell’Ambiente e nella Sanità” (NB She after having elaborated and written the project left for irremediable incompatibility in the management of the funds, 2005?)
    •  
    • PRIN 2004 Cross talk between organelles in response to oxidative stress and programmed cell death in plant -component component Unity of Molise University
    • FIRB 2003 Metodi teorici e computazionali per lo studio dell’interazione proteina-proteina e proteina-DNA (by means of  BLOSpectrum software)- component Unity of Molise University-
    • PRIN 2001 Bioenergetics: genetic, biochemistry and physiopathology
    • CNR 2000 Subcellular organelles and regulation of metabolism PRIN 1999 Bioenergetics and membrane transport -component Unity of Molise University-.
    • Mi.C.I.A. Project “Cereal Improvement for Agro-Industrial Innovations” Ministry of Agricultural Policy Project POP “Evaluation of antioxidant activity of Agro-Industrial products” Region of Molise -component Unity of Molise University.
    • +++et al.(by private mail)

    • Reviewer Activity 

    • Several Journal (high & low I.F.)

    • Journal of Biological Methods (JBM) Board Member, San Francisco, California, US from 2014
    • Different Journals  on Microbiology/Medicine/ Biotechnology Issues within   Editorial Team & technical expertise for evaluition in Academic Journals next  IF on Scopus/IsiWEb 
    • Bentham  ML PALLOTTA BENTHAM Science Ambassador from 2022
    • More of 33 years of experiences on:
    • HPLC fluorescent and UV detection
       
      Spectro/Spectrofluorimetric Techniques & Technologies
      PCR, Cloning techniques analysis of gene and protein expression,
      Enzymatic activity assays, cell viability and cytotoxic assays, generation of knock out and over-expressing
      yeast strains
      Transmembrane electrical potential (∆Ψ) assays in different metabolic conditions
      Electrophoresis
      Immunochemistry
      Polarographic oxygen analysis
      Statistical analysis
      Excellent Knowledge of graphic design applications
      Excellent Knowledge of applications of Enzymatic Kinetics, Inhibition
      Oral & Written Communication skills
      Problem solving
      Work planning & organization
      Course, meeting and events organization
      Teaching activities
      Scientific dissemination
    •  

    • HPLC fluorescent   and UV detection

    • Spectrofluorimetric techniques & technologies

    • PCR, Cloning techniques analysis of gene and protein expression, i.e. enzymatic activity assays, cell viability and cytotoxic assays, 

    • Generation of knock out and over-expressing yeast strains

    • Electrophoresis

    • Immunochemistry

    • Polarographic oxygen analyzer

    • Statistical analysis; 
    • ExCellent  command of Microsoft office tools (Word, Excel, Power Point);
    • Excellent knowledge of graphic design applications ( Corel Draw, Paint, Photoshop, BioDraw et al.)
    • Excellent knowledge of applications on Enzymatic kinetics & Inhibition  (Grafit, ecc)

    • EXPERTISE:

    • Mitochondria

    • Flavin homeostasis

    • NAD+ synthesis via NMN 1-3  enzymes

    • L-Proline metabolism,

    • D-Lactate metabolism and  transport

    • Nucleotide pool (i.e. ATP, ADP, AMP, AMPc, GDP, GTP, NMN)

    • NAD(P) + / NAD(P)H  cytosolic and mitochondrial pool

    • Riboflavin + FMN+FAD synthesis, catabolism and transport in mitochondria

    • GSH/GSSG assay

    • ROS and innovative  markers in stress conditions

    • Transmembrane electrical potential (ΔΨ) assays in different metabolic conditions

    • Specific biomarkers for improving  4P diagnostics in medicine

    • Fecal Microbiota Transplantation 

    •  

    •  

    • Knowledge, skills & attitudes  

    • oral  & written communication skills;

    • mentoring activities;

    • team working skills; 

    • problem solving;

    • work planning and organization;
    • grant writing and project management;
    • courses, meeting and events organization;
    • teaching activities;
    • scientific dissemination activities (writer /copywriter on different blog, for references pallotta@unimol.it, or pallottamarialuigia@gmail.com)
    • press office 
    • only with people good will'

       

    • for references on researches' activity 

    • Prof Cosmo Pallavicini (lab's training & mentoring) Università di Bari

      • hington

    • Profssa Claudia Sorlini Unimol.it; Università di Milano

      Prof Franco Dellaglio Unimol.it; Università Di Piacenza, Cattolica

      Profssa Sandra Torriani Università di Verona

      Prof Valerio Giaccone Unimol; Università di Torino

      Prof  Antonio Girolami Unimol.it; Universià FedericoII Napoli

      Prof Salvatore Passarella Unimol.it; Università di Bari

      Prof Donato Chiatante Unimol.it; Università Varese Insubria

      Prof Aurelio de Sanctis Università delle Marche

      Prof ssa Maria Barile Universitò di Bari

      Prof Donato Pastore Unimol; Università di Foggia

      dottssa Daniela Valenti  Unimol.it CNR, Bari

      +et NIH Scientist Emeritus, James M. Phang, M.D.,Center for Cancer Research

      National Cancer InstituteFrederick, 

       

      • Washington
    • MD 

      Pro   Erich Gneiger, Gentle Scientist,PhD Medical University of Innsbruck, D. Swarovski Research Laboratory, CEO Oroboros INSTrs

      She loved/s studying, reading, exhibitions, travelling, nature.

      She has a great ecological coscienza and partecipa attivamente a marce e convegni sulla conservazione del pianeta, agricoltura biodinamica e circolare, e energie alternative/rinnovabili, biotecnologie trandisciplinari e innovative.

      Ama la fisica nucleare e l’ottica e durante i primi anni nel laboratorio a CB, ha contribuito a realizzare uno spettrofotometro a doppia lunghezza d’onda, doppio raggio, assemblando assieme, a tandem, due spettrofotometri, al fine di analizzare i citocromi della catena respiratoria mitocondriale nelle due forme, ridotte e ossidate, contemporaneamente. La strumentazione è stata ampiamente utilizzata durante il corso interdipartimentale di Biochimica Applicata, tenuto dalla stessa in numerosi AA, nelle esercitazioni tenute dalla stessa per il corso di Biochimica del Prof Passarella ed ha prodotto contributi a convegni scientifici internazionali e altri articoli scientifici (see BBA et Bioenergetics, Pallotta et al, 2004, e altri pubblicati dai membri del team di ricerca del Prof Passarella a Cb e Ba)

      Iscritta alla CGIL dal 91, poi lavoratori della conoscenza. E’ molto sensibile ai temi sociali sin da piccola ha partecipato a convegni, marce, raduni al fine di raggiungere una equità universale e un accettabile livello di libertà culturale e di benessere condivise da tutte le componenti della società civile.

      E’ dotata di una forte spiritualità che la porta a studiare e frequentare persone & convegni/seminari che hanno come oggetto di studio la profonda conoscenza delle diverse religioni nell’individualità delle differenze e nei comuni principi etici. 

      Ama l'arte e la storia

       

      Vive in campagna, vicino ad Ostuni con marito e 2 cani corso   

       More that meets the eye


       

       

    Maria Luigia Pallotta, Biochemist/Biophysicist

  •  La solitudine sarebbe la condizione ideale se si potessero scegliere le persone da evitare

  • KK


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NB ALIAS ALL IMPOSTORS QI<<150 stay tuned!!!